Journal of Current Medical Research and Practice

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 2  |  Issue : 2  |  Page : 105--110

Doxorubicin-eluting beads versus combined conventional transarterial chemoembolization and percutaneous alcohol injection in the treatment of large hepatocellular carcinoma


Ahlam M. A. Farghaly1, EhabFawzy A Moustafa1, Hany M. A. Seif2, Moustafa H. M. Othman2, Reda H. M. Tabashy3, Mohammed O. A. Abdelglil1, Essam Eldeen M. O. Mahran1 
1 Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Assiut University, Assiut, Egypt
2 Department of Radiology, Faculty of Medicine, Assiut University, Assiut, Egypt
3 Department of Radiodiagnosis, National Cancer institute, Cairo University, Giza, Egypt

Correspondence Address:
Essam Eldeen M. O. Mahran
Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Assiut University, Assiut
Egypt

Introduction Hepatocellular carcinoma (HCC) is a primary tumor of the liver, which usually develops in the setting of chronic liver disease, particularly in patients with chronic hepatitis B and hepatitis C. Current guidelines recommend transarterial chemoembolization (TACE) as the standard treatment of Barcelona Clinic Liver Cancer-B patients. The aim of this work is to compare the efficacy, safety, feasibility, and cost-effectiveness of drug-eluting bead (DEB)-TACE versus combined conventional transarterial chemoembolization (c-TACE)+percutaneous ethanol injection (PEI) for improving the outcome of large HCC. Patients and methods In all, 75 patients with large HCC were included in this study: 30 patients were treated by combined c-TACE + PEI and 45 patients were treated by DEB-TACE. Results By comparison of the results of the combined c-TACE + PEI group with the DEB-TACE group, there was no significant difference in tumor response, with better results in the combined c-TACE + PEI group and significant decrease in the median value of the serum level of α-fetoprotein after treatment among patients treated with combined c-TACE + PEI (P = 0.004), and a statistically significant difference in the median value after treatment between the two groups (P = 0.036). Conclusion Results of combined c-TACE + PEI and DEB-TACE are comparable, but the cost of a DEB-TACE session is three times that of c-TACE + PEI, and thus cost-effectiveness analyses recommend the use of combined c-TACE + PEI (less cost) in the treatment of large HCC; in addition, there was a significant reduction in the level of α-fetoprotein after combined c-TACE+PEI treatment.


How to cite this article:
Farghaly AM, Moustafa EA, Seif HM, Othman MH, Tabashy RH, Abdelglil MO, Mahran EM. Doxorubicin-eluting beads versus combined conventional transarterial chemoembolization and percutaneous alcohol injection in the treatment of large hepatocellular carcinoma.J Curr Med Res Pract 2017;2:105-110


How to cite this URL:
Farghaly AM, Moustafa EA, Seif HM, Othman MH, Tabashy RH, Abdelglil MO, Mahran EM. Doxorubicin-eluting beads versus combined conventional transarterial chemoembolization and percutaneous alcohol injection in the treatment of large hepatocellular carcinoma. J Curr Med Res Pract [serial online] 2017 [cited 2018 Apr 27 ];2:105-110
Available from: http://www.jcmrp.eg.net/article.asp?issn=2357-0121;year=2017;volume=2;issue=2;spage=105;epage=110;aulast=Farghaly;type=0