Journal of Current Medical Research and Practice

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 2  |  Issue : 1  |  Page : 32--34

Skin level of microRNA-369-3P in patients with psoriasis and its correlation with disease severity


Eman R. M Hofny1, Hanan Morsy1, Ashraf Hasaballa2, Howida Twisy1 
1 Department of Dermatology Venereology and Andrology, Assiut University, Assiut, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt, Egypt

Correspondence Address:
Howida Twisy
Department of Dermatology Venereology and Andrology, Faculty of Medicine, Assiut University, Assiut
Egypt

Background Psoriasis is a common autoimmune skin disease characterized by intense proliferation and abnormal differentiation of keratinocytes. Recently, some microRNAs (miRs) have been proven to show an aberrant expression in psoriasis and may play a role in the pathogenesis of the disease. Objectives The aim of this study was to detect skin miR-369-3p levels in patients with psoriasis and its correlation with disease severity with measurement of one of its regulated psoriasis-related genes, SIRT, and to find the correlation between the studied parameters. Patients and methods Skin tissues were collected, and skin miR-369-3p and SIRT1 gene levels were measured. The Psoriasis Area and Severity Index scores of patients and the correlation with skin miR-369-3p levels were evaluated. Correlation between miR-369-3p and SIRT1 gene was also evaluated. Results Skin miR-369-3p levels were higher in patients with psoriasis than those in healthy controls (P = 0.01). Skin miR-369-3p had an insignificant positive linear relation with Psoriasis Area and Severity Index scores in psoriasis patients (r = 0.079, P = 0.772). Insignificant negative correlation was found between miR-369-3p and SIRT1 gene levels in skin. Conclusion The expression of miR-369-3p is increased in skin tissues from psoriasis patients. Further studies are needed to clarify the role of miR-369-3p in the pathogenesis of psoriasis.


How to cite this article:
Hofny ER, Morsy H, Hasaballa A, Twisy H. Skin level of microRNA-369-3P in patients with psoriasis and its correlation with disease severity.J Curr Med Res Pract 2017;2:32-34


How to cite this URL:
Hofny ER, Morsy H, Hasaballa A, Twisy H. Skin level of microRNA-369-3P in patients with psoriasis and its correlation with disease severity. J Curr Med Res Pract [serial online] 2017 [cited 2017 Sep 23 ];2:32-34
Available from: http://www.jcmrp.eg.net/article.asp?issn=2357-0121;year=2017;volume=2;issue=1;spage=32;epage=34;aulast=Hofny;type=0