• Users Online: 393
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2019  |  Volume : 4  |  Issue : 3  |  Page : 362-367

Initial lymphocyte count's predictive value in immune thrombocytopenic purpura


Department of Internal Medicine, Assuit University, Assuit, Egypt

Correspondence Address:
Dolagy N Naguib
Department of Internal Medicine, Assuit University, Assuit
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JCMRP.JCMRP_143_18

Rights and Permissions

Objective The objective of this study was to examine whether absolute lymphocyte count (ALC) at diagnosis correlates with the course of immune thrombocytopenia purpura (ITP) and could be considered as a prognostic factor in adults and children. Patients and methods A retrospective study of 250 patients diagnosed as having primary ITP, including 150 adult patients and 100 children, was conducted between July 2013 and July 2018 at Hematology Department and outpatient clinic. Results A highly significant decrease in mean ALC was noted in chronic ITP adult cases (1.55 ± 0.69) compared with newly diagnosed ITP cases (2.99 ± 1.23) (P = 0.000). Moreover, ALC less than 2.050/mm3 was associated with a significant risk for developing chronic ITP (P = 0.000), as only eight (26.7%) cases with ALC less than 2050/mm3 developed newly diagnosed ITP, whereas 97 cases with ALC less than 2050/mm3 (80.8%) developed chronic ITP. Thus ALC less than 2050/mm3 is considered a significant risk factor for developing chronic ITP in adults. In contrast, mean ALC in pediatric cases showed a significant decrease in chronic ITP cases (2.55 ± 1.01) compared with newly diagnosed cases (3.68 ± 1.34) (P = 0.000). Moreover, ALC less than 2050/mm3 was associated with a significant risk for developing chronic ITP (P = 0.001), as only one case less than 2050/mm3 (2.5%) developed newly diagnosed ITP, whereas 17 cases less than 2050/mm3 (28.3%) developed chronic ITP. Conclusion ALCs at diagnosis is statistically a strong predictor of the development of chronic ITP in adult and pediatric patients. ALC at cutoff less than 2050/mm3 is considered a significant risk factor for developing chronic ITP in adults and pediatric cases (P = 0.000 and 0.001, respectively).


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed151    
    Printed8    
    Emailed0    
    PDF Downloaded15    
    Comments [Add]    

Recommend this journal